Impact of Pre-Existing Immunity on Live Attenuated Influenza Vaccine-Induced Cross-Protective Immunity
نویسندگان
چکیده
منابع مشابه
Correlates of Immunity to Influenza as Determined by Challenge of Children with Live, Attenuated Influenza Vaccine
Background. The efficacy of live, attenuated live attenuated influenza vaccine(LAIV) and inactivated influenza vaccine(IIV) is poorly explained by either single or composite immune responses to vaccination. Protective biomarkers were therefore studied in response to LAIV or IIV followed by LAIV challenge in children. Methods. Serum and mucosal responses to LAIV or IIV were analyzed using immu...
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Roughly a million cases of herpes zoster (HZ) occur annually in US adults, and nearly one third of these patients will experience postherpetic neuralgia (PHN) lasting for ≥1 month [1]. The burden of HZ is strongly influenced by age: the incidence of HZ increases many fold throughout adulthood, and among adults who experience HZ, the risk that PHN will develop increases several fold more after t...
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In order to evaluate the role of persisting virus replication during occult phase immunisation in the live attenuated SIV vaccine model, a novel SIVmac239Δnef variant (SIVrtTA) genetically engineered to replicate in the presence of doxycycline was evaluated for its ability to protect against wild-type SIVmac239. Indian rhesus macaques were vaccinated either with SIVrtTA or with SIVmac239Δnef. D...
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BACKGROUND Leptospira species cause leptospirosis, a zoonotic disease found worldwide. Current vaccines against leptospirosis provide protection only against closely related serovars. METHODS We evaluated an attenuated transposon mutant of Leptospira interrogans serovar Manilae (M1352, defective in lipopolysaccharide biosynthesis) as a live vaccine against leptospirosis. Hamsters received a s...
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ژورنال
عنوان ژورنال: Vaccines
سال: 2020
ISSN: 2076-393X
DOI: 10.3390/vaccines8030459